A small-molecule antivirulence agent for treatingClostridium difficileinfection
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چکیده
منابع مشابه
A small-molecule antivirulence agent for treating Clostridium difficile infection.
Clostridium difficile infection (CDI) is a worldwide health threat that is typically triggered by the use of broad-spectrum antibiotics, which disrupt the natural gut microbiota and allow this Gram-positive anaerobic pathogen to thrive. The increased incidence and severity of disease coupled with decreased response, high recurrence rates, and emergence of multiple antibiotic-resistant strains h...
متن کاملResponse to Comment on "A small-molecule antivirulence agent for treating Clostridium difficile infection".
Ebselen's antivirulence activity in Clostridium difficile infection is likely due to multiple modes of action, but the contribution of each to its efficacy remains unclear.
متن کاملComment on "A small-molecule antivirulence agent for treating Clostridium difficile infection".
New insights into the mechanism of action of ebselen, a small-molecule antivirulence agent that reduces disease pathology in a mouse model of Clostridium difficile infection, suggest a different molecular target may be responsible for its efficacy.
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Malaria parasite strains have emerged to tolerate the therapeutic effects of the prophylactics and drugs presently available. This resistance now poses a serious challenge to researchers in the bid to overcome malaria parasitic infection. Recent studies have shown that FK520 and its analogs inhibit malaria parasites growth by binding to FK506 binding proteins (FKBPs) of the parasites. Structure...
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n engl j med 358;26 www.nejm.org june 26, 2008 2829 cokinetics and pharmacodynamics of rivaroxaban — an oral, direct factor Xa inhibitor — in patients undergoing major orthopaedic surgery. Clin Pharmacokinet 2008;47:203-16. Guerrini M, Beccati D, Shriver Z, et al. Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events. Nat Biotechnol (in press). Kis...
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ژورنال
عنوان ژورنال: Science Translational Medicine
سال: 2015
ISSN: 1946-6234,1946-6242
DOI: 10.1126/scitranslmed.aac9103